Uric acid is the final oxidation product of purine metabolism in humans. Xanthine
oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric …

Xanthine oxidase (XO) is the enzyme responsible for the catabolism of purines and their
conversion into uric acid. XO is thus the target for the treatment of hyperuricemia and gout …

Introduction Xanthine oxidase (XO) is a molybdoflavoprotein that catalyzes the oxidative
hydroxylation of purines to produce uric acid and reactive oxygen species. These reaction …

Flavonoids, a series of compounds with a C6-C3-C6 structure, mostly originate from plant
metabolism. Flavonoids have shown beneficial effects on many aspects of human …

Objective: To observe the antioxidative effects of N-(9, 10-anthraquinone-2-ylcarbonyl)
xanthine oxidase inhibitors (NAY) in vitro and in vivo models of hyperuricemia and explore …

Neuroinflammation is a key contributor to neuronal damage in neurodegenerative diseases.
In our previous work on natural effective neuroinflammatory inhibitors, Alhagi sparsifolia …

Gout is the second largest metabolic disease worldwide after diabetes, with acute gouty
arthritis as most common symptom. Xanthine oxidase (XOD) and the NOD like receptor-3 …

Anti-cancer peptides play an important role in the area of cancer inhibition. A variety of anti-
cancer peptides have emerged through the extraction and structural modification of peptides …

This research investigated the general high-throughput synthetic protocol for the accelerated
synthesis of functionalized trifluoromethylpyrazolopyrimidines 3 and N-(5-cyano-3-methyl-1 …

1. 緒言多環式芳香族複素環化合物は三環式以上でかつ複素環を一つ以上含む芳香族化合物の
総称であり, π 共役系が延長した平面性の高い構造を有している. また, これら化合物では縮合環 …