THE purpose of this review is to evaluate recent developments in our understanding of the
inflammatory response to cardiac surgery. Scientific knowledge in this field is continually …

Cytochrome P450s enzymes catalyze the metabolism of arachidonic acid to
epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and …

Background and Purpose—Mitochondrial ATP-sensitive potassium (mitoKATP) channels
are present in the brain, and several reports have shown that mitoKATP channel openers …

Objectives: Although retrograde cerebral perfusion has become a popular adjunctive
technique and may improve cerebral ischemic tolerance during hypothermic circulatory …

Deep hypothermic circulatory arrest (DHCA) has been used for the past 50 years in the
surgical repair of complex congenital cardiac malformations and operations involving the …

Background. Ischemic preconditioning is an endogenous mechanism whereby brief periods
of ischemia render neurons resistant to subsequent lethal insults. This protection appears to …

Objective Lidocaine is one of the most widely used local anesthetics with well-known
pharmacological properties. The purpose of this systematic review is to investigate the …

Even in milder cases, neurologic complications related to cardiac surgery increase mortality,
hospitalization time, and rehabilitation costs, and so contribute to the decrease in quality of …

BACKGROUND: Prolonged hypothermic circulatory arrest results in neuronal cell death and
neurologic injury. We have previously shown that hypothermic circulatory arrest causes both …

Cognitive decline is a common complication after cardiac surgery with cardiopulmonary
bypass (CPB), but as such no pharmacological therapy has been shown to be efficacious in …