Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases

M Chen, R Rong, X Xia - Journal of neuroinflammation, 2022 - Springer
Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption
and subsequent release of cellular contents and pro-inflammatory mediators (cytokines) …

Essential role of NLRP3 inflammasome in mediating IL-1β production and the pathobiology of Staphylococcus aureus endophthalmitis

A Kumar, PK Singh, Z Ahmed, S Singh… - Infection and …, 2022 - Am Soc Microbiol
Staphylococcal endophthalmitis is one of the leading causes of blindness following ocular
surgery and trauma. Dysregulated inflammation during bacterial endophthalmitis causes …

RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis

H Guo, HS Koehler, ES Mocarski, RD Dix - PLoS Pathogens, 2022 - journals.plos.org
Invasion of the brain by herpes simplex virus 1 (HSV1) can lead to the development of
herpes simplex encephalitis (HSE) that is often associated with significant morbidity and …

[HTML][HTML] The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the …

Y Kubo, MB Hans, T Nakamura… - International Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Host restriction factor GBP2 suppresses the replication of the ecotropic Moloney murine
leukemia virus (E-MLV) by inhibiting furin protease, which cleaves the viral envelope …

A mouse model that mimics AIDS-related cytomegalovirus retinitis: insights into pathogenesis

JJ Oh, JJ Carter, RD Dix - Pathogens, 2021 - mdpi.com
With the appearance of the worldwide AIDS pandemic four decades ago came a number of
debilitating opportunistic infections in patients immunosuppressed by the pathogenic human …