Beyond genetics: driving cancer with the tumour microenvironment behind the wheel
Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …
fuelled by studies showing that ageing tissues are often riddled with clones of complex …
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening
A mechanistic connection between aging and development is largely unexplored. Through
profiling age-related chromatin and transcriptional changes across 22 murine cell types …
profiling age-related chromatin and transcriptional changes across 22 murine cell types …
Epidermal stem cells: Skin surveillance and clinical perspective
X Tang, J Wang, J Chen, W Liu, P Qiao, H Quan… - Journal of Translational …, 2024 - Springer
The skin epidermis is continually influenced by a myriad of internal and external elements.
At its basal layer reside epidermal stem cells, which fuels epidermal renovation and hair …
At its basal layer reside epidermal stem cells, which fuels epidermal renovation and hair …
Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices
Lineage plasticity—a state of dual fate expression—is required to release stem cells from
their niche constraints and redirect them to tissue compartments where they are most …
their niche constraints and redirect them to tissue compartments where they are most …
Exploring the reciprocity between pioneer factors and development
MM Freund, MM Harrison, EF Torres-Zelada - Development, 2024 - journals.biologists.com
Development is regulated by coordinated changes in gene expression. Control of these
changes in expression is largely governed by the binding of transcription factors to specific …
changes in expression is largely governed by the binding of transcription factors to specific …
Pioneer factors: roles and their regulation in development
Pioneer factors are a subclass of transcription factors that can bind and initiate opening of
silent chromatin regions. Pioneer factors subsequently regulate lineage-specific genes and …
silent chromatin regions. Pioneer factors subsequently regulate lineage-specific genes and …
The yin and yang of pioneer transcription factors: Dual roles in repression and activation
Pioneer transcription factors, by virtue of their ability to target nucleosomal DNA in silent
chromatin, play crucial roles in eliciting cell fate decisions during development and cellular …
chromatin, play crucial roles in eliciting cell fate decisions during development and cellular …
Single Cell Deletion of the Transcription Factors Trps1 and Sox9 in Astrocytes Reveals Novel Functions in the Adult Cerebral Cortex
P Natarajan, C Koupourtidou, T de Resseguier… - Glia, 2024 - Wiley Online Library
Astrocytes play key roles in brain function, but how these are orchestrated by transcription
factors (TFs) in the adult brain and aligned with astrocyte heterogeneity is largely unknown …
factors (TFs) in the adult brain and aligned with astrocyte heterogeneity is largely unknown …
A pattern emerges in chromatin aging: AP-1 steals the show
CJ Lynch, L Richart, M Serrano - Cell Metabolism, 2024 - Elsevier
During aging, transcriptional programs of cell identity are partially eroded, reducing cellular
fitness and resilience. Patrick et al. 1 unveil a general mechanism for this process that …
fitness and resilience. Patrick et al. 1 unveil a general mechanism for this process that …
Promoting epithelial regeneration in chemically induced acute lung injury through Sox9-positive alveolar type 2 epithelial cells
C Cao, O Memete, Y Dun, L Zhang, F Liu, D He… - Stem Cell Research & …, 2025 - Springer
Background Chemical-induced acute lung injury is characterized by impaired epithelial
regenerative capacity, leading to acute pulmonary edema. Numerous studies have …
regenerative capacity, leading to acute pulmonary edema. Numerous studies have …