Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …

Cytokines consist of peptides, proteins and glycoproteins, which are biological signaling
molecules, and boost cell-cell communication in immune reactions to stimulate cellular …

Escherichia coli continues to be a popular expression host for the production of proteins, yet
successful recombinant expression of active proteins to high yields remains a trial and error …

Simple Summary Focal cryoablation is an FDA-approved minimally-invasive treatment for
certain kidney, colon, lung, breast, and prostate cancers. However, it is difficult to ensure …

Human interleukin-12 (hIL-12) is a heparin-binding cytokine whose activity was previously
shown to be enhanced by heparin and other sulfated glycosaminoglycans. The current study …

Cancer immunotherapy approaches have progressed significantly during the last decade
due to the significant improvement of our understanding of immunologic evasion of …

Glycosaminoglycans (GAGs), especially heparin and heparan sulfate (HS), modulate the
functions of numerous cytokines. The aims of this multidisciplinary research were to …

Immunotherapies are a powerful strategy to treat cancer by modulating the immune system
to raise an anti-tumor immune response. A prime example of immunotherapies are cytokines …

One of the main problems of modern health care is the growing number of oncological
diseases both in the elderly and young population. Inadequately effective chemotherapy …

Localized delivery of immunotherapeutics within a tumor has the potential to reduce
systemic toxicities and improve treatment outcomes in cancer patients. Unfortunately, local …