Alpha-Ketoglutarate dietary supplementation to improve health in humans

B Gyanwali, ZX Lim, J Soh, C Lim, SP Guan… - Trends in Endocrinology …, 2022 - cell.com
Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various
metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia …

The antioxidative function of alpha‐ketoglutarate and its applications

S Liu, L He, K Yao - BioMed research international, 2018 - Wiley Online Library
Alpha‐ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical
role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the …

Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent

MM Bayliak, VI Lushchak - Ageing research reviews, 2021 - Elsevier
An intermediate of tricarboxylic acid cycle alpha-ketoglutarate (AKG) is involved in
pleiotropic metabolic and regulatory pathways in the cell, including energy production …

Measurement of solid food intake in Drosophila via consumption-excretion of a dye tracer

BC Shell, RE Schmitt, KM Lee, JC Johnson… - Scientific reports, 2018 - nature.com
Although the Drosophila melanogaster (fly) model is a popular platform for investigating diet-
related phenomena, it can be challenging to measure the volume of agar-based food media …

Combined transcriptomic and metabolomic analyses uncover rearranged gene expression and metabolite metabolism in tobacco during cold acclimation

J Xu, Z Chen, F Wang, W Jia, Z Xu - Scientific Reports, 2020 - nature.com
Cold temperatures often severely restrict the growth, distribution and productivity of plants.
The freezing tolerance of plants from temperate climates can be improved by undergoing …

Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)—intervention study protocol

E Sandalova, J Goh, ZX Lim, ZM Lim, D Barardo… - Geroscience, 2023 - Springer
Targeting molecular processes of aging will enable people to live healthier and longer lives
by preventing age-related diseases. Geroprotectors are compounds with the potential to …

[HTML][HTML] Sustained therapeutic effects of self-assembled hyaluronic acid nanoparticles loaded with α-Ketoglutarate in various osteoarthritis stages

X Wang, Y Xue, K Hao, B Peng, H Chen, H Liu, J Wang… - Biomaterials, 2025 - Elsevier
Osteoarthritis (OA) is a prevalent degenerative disease characterized by irreversible
destruction of articular cartilage, for which no current drugs are known to modify its …

Comparative proteomic analysis reveals novel insights into the continuous cropping induced response in Scrophularia ningpoensis

J Sun, X Li, Z Qu, H Wang, Y Cheng… - Journal of the …, 2023 - Wiley Online Library
BACKGROUND Scrophularia ningpoensis is a well‐known medicinal crop. Continuous
cropping seriously affects the yield and quality, but little is known about the influence of …

Dietary L-arginine accelerates pupation and promotes high protein levels but induces oxidative stress and reduces fecundity and life span in Drosophila melanogaster

MM Bayliak, MP Lylyk, OV Maniukh, JM Storey… - Journal of Comparative …, 2018 - Springer
Abstract l-Arginine, a precursor of many amino acids and of nitric oxide, plays multiple
important roles in nutrient metabolism and regulation of physiological functions. In this study …

[HTML][HTML] Alpha-ketoglutarate partially alleviates effects of high-fat high-fructose diet in mouse muscle

MV Vatashchuk, MM Bayliak, VV Hurza… - EXCLI …, 2023 - ncbi.nlm.nih.gov
Consumption of high-calorie diets leads to excessive accumulation of storage lipids in
adipose tissue. Metabolic changes occur not only in adipose tissue but in other tissues, too …