Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …

The intestinal microbiota composition and associated bioactivities are sensitive to various
modifier cues such as stress, inflammation, age, life-style and nutrition, which in turn are …

The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity
and obesity-related morbidities remains unknown. We explored how the interaction between …

The interplay between gut microbiota and the host immune system is emerging as a factor in
the pathogenesis of colorectal cancer. Here, we set out to identify the effect of Akkermansia …

Objective Gut microbiota have been linked to inflammatory bowel disease (IBD) and
colorectal cancer (CRC). Akkermansia muciniphila (A. muciniphila) is a gram-negative …

Background Breast cancer is considered to result from a combination of genetic and lifestyle-
related factors, but the degree to which an overall healthy lifestyle may attenuate the impact …

Cancer site–specific polygenic risk scores (PRS) effectively identify individuals at high risk of
individual cancers, but the effectiveness of PRS on overall cancer risk assessment and the …

Background The incidence of colorectal cancer (CRC) among individuals aged younger
than 50 years has been increasing. As screening guidelines lower the recommended age of …

Background & Aims Estimates of absolute risk of colorectal cancer (CRC) are needed to
facilitate communication and better inform the public about the potentials and limits of cancer …

Background The interplay between gut microbiota and tumor microenvironment (TME) in the
pathogenesis of colorectal cancer (CRC) is not well explored. Here, we elucidated the …