Hydrogen peroxide is an aerobic metabolite playing a central role in redox signaling and
oxidative stress. H 2 O 2 could activate redox sensitive transcription factors, such as Nrf2, AP …

Reactive oxygen species are generated by multiple mechanisms during contractile activity in
exercising skeletal muscle and are recognised to play a role in signaling adaptations to the …

Loss of innervation is a key driver of age associated muscle atrophy and weakness
(sarcopenia). Our laboratory has previously shown that denervation induced atrophy is …

Whole-body knock-out of Cu, Zn superoxide dismutase (Sod1KO) results in accelerated, age-
related loss of muscle mass and function associated with neuromuscular junction (NMJ) …

Musculoskeletal health is directly linked to independence and longevity, but disease and
aging impairs muscle mass and health. Complete repair after a pathological or physiological …

Responding appropriately to exercise is essential to maintenance of skeletal muscle mass
and function at all ages and particularly during aging. Here, a hypothesis is presented that a …

Skeletal muscle generates superoxide during contractions, which is converted to hydrogen
peroxide (H 2 O 2). H 2 O 2 has been proposed to activate signalling pathways and …

Musculoskeletal disorders and age-related musculoskeletal decline are major contributors
to the burden of ill health seen in older subjects. Despite this increased burden, these …

Motor unit remodelling involving repeated denervation and re-innervation occurs throughout
life. The efficiency of this process declines with age contributing to neuromuscular deficits …

Skeletal muscles are crucial structures within the vertebrate musculoskeletal system and
contain inherent heterogeneities in both their anatomy (ie extrafusal and intrafusal muscle …