The mercapturic acid pathway

PE Hanna, MW Anders - Critical reviews in toxicology, 2019 - Taylor & Francis
The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

Structures of leukotriene biosynthetic enzymes and development of new therapeutics

JZ Haeggström, ME Newcomer - Annual review of …, 2023 - annualreviews.org
Leukotrienes are potent immune-regulating lipid mediators with patho-genic roles in
inflammatory and allergic diseases, particularly asthma. These autacoids also contribute to …

From cyanobacteria to human, MAPEG-type glutathione-S-transferases operate in cell tolerance to heat, cold, and lipid peroxidation

X Kammerscheit, F Chauvat… - Frontiers in …, 2019 - frontiersin.org
The MAPEG2 sub-family of glutathione-S-transferase proteins (GST) has been poorly
investigated in vivo, even in prokaryotes such as cyanobacteria the organisms that are …

Integral membrane enzymes in eicosanoid metabolism: structures, mechanisms and inhibitor design

M Thulasingam, JZ Haeggström - Journal of molecular biology, 2020 - Elsevier
Eicosanoids are potent lipid mediators involved in central physiological processes such as
hemostasis, renal function and parturition. When formed in excess, eicosanoids become …

Enzymology of reactive intermediate protection: kinetic analysis and temperature dependence of the mesophilic membrane protein catalyst MGST1

M Cebula, R Morgenstern - The FEBS Journal, 2023 - Wiley Online Library
Glutathione transferases (GSTs) are a class of phase II detoxifying enzymes catalysing the
conjugation of glutathione (GSH) to endogenous and exogenous electrophilic molecules …

Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation

Q Kuang, P Purhonen, J Ålander, R Svensson… - Scientific Reports, 2017 - nature.com
Abstract Microsomal glutathione transferase 1 (MGST1) is a detoxification enzyme
belonging to the Membrane Associated Proteins in Eicosanoid and Glutathione Metabolism …

Kinetic Behavior of Glutathione Transferases: Understanding Cellular Protection from Reactive Intermediates

R Morgenstern - Biomolecules, 2024 - mdpi.com
Glutathione transferases (GSTs) are the primary catalysts protecting from reactive
electrophile attack. In this review, the quantitative levels and distribution of glutathione …

[HTML][HTML] Reactive oxygen and nitrogen species regulate porcine embryo development during pre-implantation period: A mini-review

Z Luo, J Yao, J Xu - Animal Nutrition, 2021 - Elsevier
Significant porcine embryonic loss occurs during conceptus morphological elongation and
attachment from d 10 to 20 of pregnancy, which directly decreases the reproductive …

Part-of-the-sites binding and reactivity in the homooligomeric enzymes–facts and artifacts

B Wielgus-Kutrowska, T Grycuk, A Bzowska - Archives of biochemistry and …, 2018 - Elsevier
For a number of enzymes composed of several subunits with the same amino acid
sequence, it was documented, or suggested, that binding of a ligand, or catalysis, is carried …

Microsomal glutathione transferase 1 attenuated ROS-induced lipid peroxidation in Apostichopus japonicus

Z Zhang, Z Lv, Y Shao, Q Qiu, W Zhang, X Duan… - Developmental & …, 2017 - Elsevier
Microsomal glutathione transferase (mGST) is a membrane bound glutathione transferase in
multifunctional detoxification isoenzymes family and also plays crucial roles in innate …