Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …

T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining
immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in …

Psoriasis is a chronic inflammatory disease with a strong genetic component that can be
triggered by environmental factors. Disease pathogenesis is mainly driven by type 1 and …

The role of dysbiosis in food allergy (FA) remains unclear. We found that dysbiotic fecal
microbiota in FA infants evolved compositionally over time and failed to protect against FA in …

Regulatory T cells (Treg cells) are key players in ensuring a peaceful coexistence with
microorganisms and food antigens at intestinal borders. Startling new information has …

Gut commensal microbes shape the mucosal immune system by regulating the
differentiation and expansion of several types of T cell,,,,. Clostridia, a dominant class of …

Gut-resident forkhead box P3 (FOXP3)+ CD4+ regulatory T cells (Treg cells) are distinct from
those in other organs and have gut-specific phenotypes and functions. Whereas Treg cells …

CD4+ T cells are crucial for directing appropriate immune responses during host defense
and for the pathogenesis of inflammatory diseases. In addition to the classical biphasic …

Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …