Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

Lysine acetylation is a reversible posttranslational modification of proteins and plays a key
role in regulating gene expression. Technological limitations have so far prevented a global …

Protein post‐translational modifications (PTM s) allow the cell to regulate protein activity and
play a crucial role in the response to changes in external conditions or internal states …

To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence
of latently infected cells. The 'shock and kill'approach to a cure proposes to eliminate this …

HIV-1 can infect both activated and resting, non-dividing cells, following which the viral
genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs …

Comprehensively elucidating the molecular mechanisms of human immunodeficiency virus
type 1 (HIV-1) latency is a priority to achieve a functional cure. As current'shock'agents failed …

General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of
the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase …