Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

GPR52 is a class-A orphan G-protein-coupled receptor that is highly expressed in the brain
and represents a promising therapeutic target for the treatment of Huntington's disease and …

Background Huntington's disease (HD) is an incurable hereditary neurodegenerative
disorder, which manifests itself as a loss of GABAergic medium spiny (GABA MS) neurons in …

Highlights•GPCRs are implicated in the pathophysiology of various neurodegenerative
diseases.•Currently available therapies do not cure the discussed neurodegenerative …

Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …

Huntington's disease (HD) is a fatal neurodegenerative disorder due to an extraordinarily
expanded CAG repeat in the huntingtin gene that confers a gain-of-toxic function in the …

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG
repeat expansion in the huntingtin gene (HTT). The new insights into HD's cellular and …

G protein-coupled receptors (GPCRs) are the most common targets of the
neuropharmacological drugs in the central nervous system (CNS). GPCRs are activated by …

Most research on neurodegenerative diseases has focused on neurons, yet glia help form
and maintain the synapses whose loss is so prominent in these conditions. To investigate …