Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

Somatic stem cell populations participate in the development and regeneration of their host
tissues. Skeletal muscle is capable of complete regeneration due to stem cells that reside in …

The decline of tissue regenerative potential is a hallmark of ageing and may be due to age-
related changes in tissue-specific stem cells,,,,. A decline in skeletal muscle stem cell …

A major obstacle in the application of cell-based therapies for the treatment of
neuromuscular disorders is obtaining the appropriate number of stem/progenitor cells to …

Satellite cells reside beneath the basal lamina of skeletal muscle fibers and include cells
that act as precursors for muscle growth and repair. Although they share a common …

The concept of a post-natal “mesenchymal stem cell”(“MSC”) originated from studies
focused on bone marrow stromal cells (BMSCs), which are non-hematopoietic adherent …

Skeletal muscle regeneration in adults is thought to occur through the action of myogenic
satellite cells located in close association with mature muscle fibers; however, these …

Adult skeletal muscle generates force in a controlled and directed manner through the
contraction of highly specialized, postmitotic, multinucleated myofibers. Life-long muscle …

Little progress has been made toward the use of embryonic stem (ES) cells to study and
isolate skeletal muscle progenitors. This is due to the paucity of paraxial mesoderm …

A vast literature exists on the biology of blood formation and regeneration under
experimental and clinical conditions. The field of hematopoiesis was recently advanced by …