The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

The cardiac autonomic nervous system (CANS) plays a key role for the regulation of cardiac
activity with its dysregulation being involved in various heart diseases, such as cardiac …

The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …

Abstract This Committee Report provides methodological, interpretive, and reporting
guidance for researchers who use measures of heart rate (HR) and heart rate variability …

Gq proteins are universally important for signal transduction in mammalian cells. The
underlying kinetics and transformation from extracellular stimuli into intracellular signaling …

Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …

Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and
contractile force. In the present study, we uncover the primary mechanism underlying the …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are the molecular
correlate of the If current and are critically involved in controlling neuronal excitability and …

Atrial fibrillation (AF) is prevalent in common conditions and acquired forms of heart disease,
including diabetes mellitus (DM), hypertension, cardiac hypertrophy, and heart failure. AF is …

Soft robotic actuation concepts meet and sometimes exceed their natural counterparts. In
contrast, artificially recreating natural levels of autonomy is still an unmet challenge. Here …