Synthetic biology: bottom-up assembly of molecular systems
The bottom-up assembly of biological and chemical components opens exciting
opportunities to engineer artificial vesicular systems for applications with previously unmet …
opportunities to engineer artificial vesicular systems for applications with previously unmet …
Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …
immune responses. They also provide a frontline of host defense in the central nervous …
Acidic nanoparticles restore lysosomal acidification and rescue metabolic dysfunction in pancreatic β-cells under lipotoxic conditions
Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …
Endocytosis-like vesicle fission mediated by a membrane-expanding molecular machine enables virus encapsulation for in vivo delivery
N Uchida, Y Ryu, Y Takagi, K Yoshizawa… - Journal of the …, 2023 - ACS Publications
Biological membranes are functionalized by membrane-associated protein machinery.
Membrane-associated transport processes, such as endocytosis, represent a fundamental …
Membrane-associated transport processes, such as endocytosis, represent a fundamental …
A practical guide to preparation and applications of giant unilamellar vesicles formed via centrifugation of water-in-oil emulsion droplets
Giant vesicles (GVs), which are closed lipid bilayer membranes with a diameter of more than
1 μm, have attracted attention not only as model cell membranes but also for the …
1 μm, have attracted attention not only as model cell membranes but also for the …
Advancing the design of artificial nano-organelles for targeted cellular detoxification of reactive oxygen species
V Maffeis, M Skowicki, KMP Wolf, M Chami… - Nano Letters, 2024 - ACS Publications
Artificial organelles (AnOs) are in the spotlight as systems to supplement biochemical
pathways in cells. While polymersome-based artificial organelles containing enzymes to …
pathways in cells. While polymersome-based artificial organelles containing enzymes to …
Synthetic Cells Revisited: Artificial Cells Construction Using Polymeric Building Blocks
The exponential growth of research on artificial cells and organelles underscores their
potential as tools to advance the understanding of fundamental biological processes. The …
potential as tools to advance the understanding of fundamental biological processes. The …
TNF receptors: Structure-function relationships and therapeutic targeting strategies
CH Lo - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2024 - Elsevier
Tumor necrosis factor receptors (TNFR1 and TNFR2) play key roles in mediating
inflammatory response and cell death signaling, which are associated with autoimmune …
inflammatory response and cell death signaling, which are associated with autoimmune …
Rotational dynamics of a disk in a thin film of weakly nematic fluid subject to linear friction
Dynamics at low Reynolds numbers experiences recent revival in the fields of biophysics
and active matter. While in bulk isotropic fluids it is exhaustively studied, this is less so in …
and active matter. While in bulk isotropic fluids it is exhaustively studied, this is less so in …
Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration
Obesity is a major modifiable risk factor leading to neuroinflammation and
neurodegeneration. Excessive fat storage in obesity promotes the progressive infiltration of …
neurodegeneration. Excessive fat storage in obesity promotes the progressive infiltration of …