In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …

Each gene of the tubby-like family is characterized by a signature of C-terminal tubby
domain. The wide spread of this family in plants and animals implies they have an important …

Rod photoreceptor synapses use large, ribbon-type active zones for continuous synaptic
transmission during light and dark. Since ribbons are physically connected to the active …

Ribbon synapses reliably transmit synaptic signals over a broad signalling range. Rod
photoreceptor ribbon synapses are capable of transmitting signals generated by the …

Following exocytosis at active zones, synaptic vesicle membranes and membrane-bound
proteins must be recycled. The endocytic machinery that drives this recycling accumulates in …

Optic neuritis is one of the first manifestations of multiple sclerosis. Its pathogenesis is
incompletely understood, but considered to be initiated by an auto‐immune response …

Background: Multiple sclerosis is a frequent neuroinflammatory and neurodegenerative
disease of the central nervous system that includes alterations in the white and gray matter …

Synaptic ribbons are presynaptic protein complexes that are believed to be important for the
transmission of sensory information in the visual system. Ribbons are selectively associated …

Retinal photoreceptors are neurons that convert dynamically changing patterns of light into
electrical signals that are processed by retinal interneurons and ultimately transmitted to …

Plasticity in sensory signaling is partly mediated via regulated trafficking of signaling
molecules to and from primary cilia. Tubby-related proteins regulate ciliary protein transport; …