Renewal in human fear conditioning: A systematic review and meta-analysis

Y Wang, S Olsson, OV Lipp, LJ Ney - Neuroscience & Biobehavioral …, 2024 - Elsevier
Renewal is a 'return of fear'manipulation in human fear conditioning to investigate learning
processes underlying anxiety and trauma. Even though renewal paradigms are widely used …

Integrating threat conditioning and the hierarchical taxonomy of psychopathology to advance the study of anxiety-related psychopathology.

SE Cooper, ER Perkins, RD Webler… - … and Clinical Science, 2024 - psycnet.apa.org
Theoretical and methodological research on threat conditioning provides important
neuroscience-informed approaches to studying fear and anxiety. The threat conditioning …

Pavlovian or associative sensitization and its biological significance

M Domjan, MS Fanselow - Neuroscience & Biobehavioral Reviews, 2024 - Elsevier
Pavlovian conditioning is typically distinguished from sensitization but a Pavlovian
conditional stimulus (CS) also results in sensitization. A Pavlovian CS can sensitize …

An honest reckoning with the amygdala and mental illness

AS Fox, AJ Shackman - American Journal of Psychiatry, 2024 - psychiatryonline.org
Anxiety disorders are a leading source of human misery, morbidity, and premature mortality.
Existing treatments are far from curative for many, underscoring the need to clarify the …

Semantic structures facilitate threat memory integration throughout the medial temporal lobe and medial prefrontal cortex

SE Cooper, AC Hennings, SA Bibb, JA Lewis-Peacock… - Current Biology, 2024 - cell.com
Emotional experiences can profoundly impact our conceptual model of the world, modifying
how we represent and remember a host of information even indirectly associated with that …

Understanding clinical fear and anxiety through the lens of human fear conditioning

T Beckers, D Hermans, I Lange, L Luyten… - Nature Reviews …, 2023 - nature.com
Fear is an adaptive emotion that mobilizes defensive resources upon confrontation with
danger. However, fear becomes maladaptive and can give rise to the development of …

Fear conditioning depends on the nature of the unconditional stimulus and may be related to hair levels of endocannabinoids

LJ Ney, DS Nichols, OV Lipp - Psychophysiology, 2023 - Wiley Online Library
The replicability of fear conditioning research has come under recent scrutiny, with
increasing acknowledgment that the use of differing materials and methods may lead to …

[HTML][HTML] Fear and Safety Learning in Anxiety-and Stress-Related Disorders: An Updated Meta-Analysis

FM Kausche, HP Carsten, KM Sobania… - … & Biobehavioral Reviews, 2024 - Elsevier
Fear learning processes are believed to play a crucial role in the development and
maintenance of anxiety and stress-related disorders. To integrate results across different …

Neural correlates of immediate versus delayed extinction when simultaneously varying the time of the test in humans

M Kampa, A Hermann, R Stark, T Klucken - Cerebral Cortex, 2023 - academic.oup.com
Anxiety disorders are effectively treated with exposure therapy based on the extinction of
Pavlovian fear conditioning. Animal research indicates that both the timing of extinction and …

[HTML][HTML] Fear extinction retention in children, adolescents, and adults

E Widegren, J Vegelius, MA Frick, AA Roy… - Developmental …, 2025 - Elsevier
Past results suggest that fear extinction and the return of extinguished fear are compromised
in adolescents. However, findings have been inconclusive as there is a lack of fear …