Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

Acinetobacter baumannii Resistance: A Real Challenge for Clinicians

R Vázquez-López, SG Solano-Gálvez… - Antibiotics, 2020 - mdpi.com
Acinetobacter baumannii (named in honor of the American bacteriologists Paul and Linda
Baumann) is a Gram-negative, multidrug-resistant (MDR) pathogen that causes nosocomial …

Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies

Y Cai, D Chai, R Wang, B Liang… - Journal of antimicrobial …, 2012 - academic.oup.com
Colistin is the last resort for treatment of multidrug-resistant Acinetobacter baumannii.
Unfortunately, resistance to colistin has been reported all over the world. The highest …

The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace

I Roca, P Espinal, X Vila-Farrés, J Vila - Frontiers in microbiology, 2012 - frontiersin.org
During the past few decades Acinetobacter baumannii has evolved from being a commensal
dweller of health-care facilities to constitute one of the most annoying pathogens …

Pharmacokinetics and pharmacodynamics of 'old'polymyxins: what is new?

PJ Bergen, CB Landersdorfer, J Zhang, M Zhao… - … and infectious disease, 2012 - Elsevier
'Old'colistin and polymyxin B are increasingly used as last-line therapy against multidrug-
resistant Gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and …

In vitro synergy of polymyxins with other antibiotics for Acinetobacter baumannii: a systematic review and meta-analysis

W Ni, X Shao, X Di, J Cui, R Wang, Y Liu - International journal of …, 2015 - Elsevier
In order to provide preliminary guidance for rational antibiotic combination therapy in the
clinic, a systematic review and meta-analysis was performed to evaluate the in vitro …

Use of high-dose IV and aerosolized colistin for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia: do we really need this …

G Kalin, E Alp, H Demiraslan, M Doganay… - Journal of Infection and …, 2012 - Elsevier
In this study we aimed to assess the safety and efficacy of high-dose IV colistin (COL) and
aerosolized COL for the treatment of Acinetobacter baumannii ventilator-associated …

Pharmacokinetics and pharmacodynamics of peptide antibiotics

X Bian, X Qu, J Zhang, SC Nang, PJ Bergen… - Advanced drug delivery …, 2022 - Elsevier
Antimicrobial resistance is a major global health challenge. As few new efficacious
antibiotics will become available in the near future, peptide antibiotics continue to be major …

In vitro activity and post-antibiotic effects of colistin in combination with other antimicrobials against colistin-resistant KPC-producing Klebsiella pneumoniae …

P Gaibani, D Lombardo, RE Lewis… - Journal of …, 2014 - academic.oup.com
Objectives Combination therapy is recommended for the treatment of KPC-producing
Klebsiella pneumoniae (KPC-Kp), but the optimal regimen for colistin-resistant strains is …

Emergence and Spread of Plasmid-Borne tet(B)::ISCR2 in Minocycline-Resistant Acinetobacter baumannii Isolates

E Vilacoba, M Almuzara, L Gulone… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Resistance to minocycline has emerged in multidrug-resistant Acinetobacter baumannii
isolates from Buenos Aires hospitals. Few reports about the description and dispersion of tet …