Activity‐based protein profiling (ABPP) has matured into a standard method for the fast,
sensitive, and selective identification of enzyme activity and inhibitors in proteomes. By …

After about ten years of research renaissance in metabolism, the present challenge is to
understand how metabolic fluxes are controlled by a complex interplay of overlapping …

Arylfluorosulfates have appeared only rarely in the literature and have not been explored as
probes for covalent conjugation to proteins, possibly because they were assumed to …

Nuclear receptors (NRs) are key regulators of gene expression and physiology. Nearly half
of all human NRs lack endogenous ligands including estrogen-related receptor α (ERRα) …

Natural small compounds comprise most cellular molecules and bind proteins as substrates,
products, cofactors, and ligands. However, a large-scale investigation of in vivo protein …

Understanding the interactions between small molecules and proteins can be approached
from different perspectives and is important for the advancement of basic science and drug …

Activity based metabolomic profiling (ABMP) allows unbiased discovery of enzymatic
activities encoded by genes of unknown function, and applies liquid-chromatography mass …

With the emergence of next‐generation nucleotide sequencing and mass spectrometry‐
based proteomics and metabolomics tools, we have comprehensive and scalable methods …

Background Early detection of melanoma is of great importance to reduce mortality.
Discovering new melanoma biomarkers would improve early detection and diagnosis. Here …

Highlights•Protein–metabolite interactions are mapped using protein-centric and metabolite-
centric approaches.•Proteome-wide monitoring of ligand-induced effects enables HTP …