Viruses compartmentalize their replication and assembly machinery to both evade detection
and concentrate the viral proteins and nucleic acids necessary for genome replication and …

The Flavivirus genus consists of> 70 members including several that are considered
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …

Dengue fever represents a significant medical and socio-economic burden in (sub) tropical
regions, yet antivirals for treatment or prophylaxis are lacking. JNJ-A07 was described as …

Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a
vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close …

Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral
pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever …

Highlights•Molecular structures and predicated models of flaviviral NS proteins.•Recent
advance in antiviral development targeting NS proteins.•Inhibitors targeting NS4B entering …

Cellular factors have important roles in all facets of the flavivirus replication cycle.
Deciphering viral-host protein interactions is essential for understanding the flavivirus life …

Flaviviruses are positive-sense single-stranded RNA viruses that pose a considerable threat
to human health. Flaviviruses replicate in compartmentalized replication organelles derived …

Positive-strand RNA viruses encompass a variety of established and emerging eukaryotic
pathogens. Their genome replication is confined to specialized cytoplasmic membrane …

Positive-strand RNA viruses have been the etiological agents in several major disease
outbreaks over the last few decades. Examples of this include flaviviruses, such as dengue …