[HTML][HTML] Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review

Z Vinarov, M Abdallah, JAG Agundez… - European Journal of …, 2021 - Elsevier
The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

Biological functions of lymphatic vessels

TV Petrova, GY Koh - Science, 2020 - science.org
BACKGROUND Blood and lymphatic vessel networks form two arms of the vertebrate
cardiovascular system that play complementary roles in body homeostasis maintenance and …

Lymphatic vessels in cancer

LC Dieterich, C Tacconi, L Ducoli… - Physiological …, 2022 - journals.physiology.org
The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …

Lymphatic malformations: genetics, mechanisms and therapeutic strategies

T Mäkinen, LM Boon, M Vikkula, K Alitalo - Circulation research, 2021 - Am Heart Assoc
Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation
interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking …

[HTML][HTML] Lymphatic vessel network structure and physiology

JW Breslin, Y Yang, JP Scallan, RS Sweat… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Vascular heterogeneity and specialization in development and disease

M Potente, T Mäkinen - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

Vascular endothelial growth factor signaling in development and disease

S Karaman, VM Leppänen, K Alitalo - Development, 2018 - journals.biologists.com
Vascular endothelial growth factors (VEGFs) are best known for their involvement in
orchestrating the development and maintenance of the blood and lymphatic vascular …

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

EA Korhonen, A Murtomäki, SK Jha… - The Journal of …, 2022 - Am Soc Clin Investig
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF
receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human …

Development and plasticity of meningeal lymphatic vessels

S Antila, S Karaman, H Nurmi, M Airavaara… - Journal of Experimental …, 2017 - rupress.org
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their
possible involvement in neuropathological processes, yet little is known about their …

Lymphatic system in cardiovascular medicine

A Aspelund, MR Robciuc, S Karaman… - Circulation …, 2016 - Am Heart Assoc
The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …