Covering: 2006 to 2017 Actinomycetes have been, for decades, one of the most important
sources for the discovery of new antibiotics with an important number of drugs and analogs …

Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over
the past several decades. In this review the factors that have been linked to this …

The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

The advent of modern antibiotics contributed enormously to the dramatic extension of
human lifespan since their discovery by virtue of their lethal and selective action against …

Natural products have been the single most productive source of leads for the development
of drugs. Over a 100 new products are in clinical development, particularly as anti-cancer …

Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …

Membrane lipid homeostasis is a vital facet of bacterial cell physiology. For decades,
research in bacterial lipid synthesis was largely confined to the Escherichia coli model …

Covering: up to July 2023 Terpene cyclases (TCs) catalyze some of the most complicated
reactions in nature and are responsible for creating the skeletons of more than 95 000 …

Among the wide diversity of naturally occurring phenolic acids, at least 30 hydroxy-and
polyhydroxybenzoic acids have been reported in the last 10 years to have biological …