Trinucleotide repeat disorders
The discovery that expansion of unstable repeats can cause a variety of neurological
disorders has changed the landscape of disease-oriented research for several forms of …
disorders has changed the landscape of disease-oriented research for several forms of …
Diseases of unstable repeat expansion: mechanisms and common principles
JR Gatchel, HY Zoghbi - Nature Reviews Genetics, 2005 - nature.com
The list of developmental and degenerative diseases that are caused by expansion of
unstable repeats continues to grow, and is now approaching 20 disorders. The pathogenic …
unstable repeats continues to grow, and is now approaching 20 disorders. The pathogenic …
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia
C Lin, ER Smith, H Takahashi, KC Lai, S Martin-Brown… - Molecular cell, 2010 - cell.com
Chromosomal translocations involving the MLL gene are associated with infant acute
lymphoblastic and mixed lineage leukemia. There are a large number of translocation …
lymphoblastic and mixed lineage leukemia. There are a large number of translocation …
The super elongation complex (SEC) and MLL in development and disease
E Smith, C Lin, A Shilatifard - Genes & development, 2011 - genesdev.cshlp.org
Transcriptional regulation at the level of elongation is vital for the control of gene expression
and metazoan development. The mixed lineage leukemia (MLL) protein and its Drosophila …
and metazoan development. The mixed lineage leukemia (MLL) protein and its Drosophila …
Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
PM Ayton, ML Cleary - Oncogene, 2001 - nature.com
Abstract The MLL (Mixed Lineage Leukemia) gene is a common target for chromosomal
translocations associated with human acute leukemias. These translocations result in a gain …
translocations associated with human acute leukemias. These translocations result in a gain …
Functional genomic analysis of the Wnt-wingless signaling pathway
The Wnt-Wingless (Wg) pathway is one of a core set of evolutionarily conserved signaling
pathways that regulates many aspects of metazoan development. Aberrant Wnt signaling …
pathways that regulates many aspects of metazoan development. Aberrant Wnt signaling …
Physiological and genetic mechanisms underlying caste development, reproduction and division of labor in stingless bees
Investigations on physiological and molecular mechanisms underlying developmental and
reproductive differentiation in social bees center on the question of how different patterns of …
reproductive differentiation in social bees center on the question of how different patterns of …
Extensive polymerase pausing during Drosophila axis patterning enables high-level and pliable transcription
Cascades of zygotic gene expression pattern the anterior–posterior (AP) and dorsal–ventral
(DV) axes of the early Drosophila embryo. Here, we used the global run-on sequencing …
(DV) axes of the early Drosophila embryo. Here, we used the global run-on sequencing …
MLL fusion partners AF4 and AF9 interact at subnuclear foci
F Erfurth, CS Hemenway, AC De Erkenez, PH Domer - Leukemia, 2004 - nature.com
The MLL gene is involved in translocations associated with both acute lymphoblastic and
acute myelogenous leukemia. These translocations fuse MLL with one of over 30 partner …
acute myelogenous leukemia. These translocations fuse MLL with one of over 30 partner …
An F1 Genetic Screen for Maternal-Effect Mutations Affecting Embryonic Pattern Formation in Drosophila melanogaster
S Luschnig, B Moussian, J Krauss, I Desjeux… - Genetics, 2004 - academic.oup.com
Large-scale screens for female-sterile mutations have revealed genes required maternally
for establishment of the body axes in the Drosophila embryo. Although it is likely that the …
for establishment of the body axes in the Drosophila embryo. Although it is likely that the …