Abstract Medulloblastoma accounts for 15–20% of childhood nervous system tumours. The
risk of dying was reduced by 30% in the last twenty years. Patients are divided in risk strata …

Simple Summary Pediatric brain tumors represent a formidable challenge in the field of
oncology. Pediatric brain tumors are sub-classified into several molecular sub-types, where …

Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens …

Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …

Medulloblastoma (MB) is the most common type of brain malignancy in children. Molecular
profiling has become an important component to select patients for therapeutic approaches …

Background: The lack of success of standard therapies for medulloblastoma has highlighted
the need to plan a new therapeutic approach. The purpose of this article is to provide an …

Objective Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) and SMARCA4-
deficient undifferentiated uterine sarcoma (SMARCA4-DUS) are rare and aggressive …

Pediatric brain tumors including medulloblastoma and atypical teratoid/rhabdoid tumor are
associated with significant mortality and treatment-associated morbidity. While …

Numerous molecular factors disrupt the correctness of the cell cycle process leading to the
development of cancer due to increased cell proliferation. Among known causative factors of …

Aberrant Hedgehog signaling and excessive activation of the Gli family of transcriptional
activators are key drivers of medulloblastoma (MB), the most common human pediatric brain …