Cardiometabolic effects of psychotropic medications

O Abosi, S Lopes, S Schmitz… - … molecular biology and …, 2018 - degruyter.com
Background Many psychiatric disorders including schizophrenia, bipolar disorder and major
depression convey an excess burden of cardiovascular morbidity and mortality. The …

Preclinical models of antipsychotic drug-induced metabolic side effects

HN Boyda, L Tse, RM Procyshyn, WG Honer… - Trends in …, 2010 - cell.com
Antipsychotic drugs (APDs), and the 'atypical'APDs in particular, are commonly associated
with metabolic side effects in humans. These include glucose dysregulation, insulin …

Olanzapine treatment and metabolic dysfunction: a dose response study in female Sprague Dawley rats

K Weston-Green, XF Huang, C Deng - Behavioural brain research, 2011 - Elsevier
Second generation antipsychotics are commonly prescribed for the treatment of
schizophrenia, however some can induce metabolic dysfunction side-effects such as weight …

[HTML][HTML] Effect of alpha-mangostin on olanzapine-induced metabolic disorders in rats

A Ardakanian, MG Rahbardar… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Objective (s): As olanzapine has side effects such as weight gain and metabolic disorders,
and alpha-mangostin has been shown to control metabolic disorders, the effects of alpha …

Insulin resistance and decreased glucose-stimulated insulin secretion after acute olanzapine administration

AF Chintoh, SW Mann, L Lam, C Lam… - Journal of clinical …, 2008 - journals.lww.com
The newer atypical antipsychotics, as a class, have been associated with an increased risk
of weight gain and metabolic abnormalities. The mechanisms underlying this phenomenon …

Combined sulforaphane and β-sitosterol mitigate olanzapine-induced metabolic disorders in rats: Insights on FOXO, PI3K/AKT, JAK/STAT3, and MAPK signaling …

EAM El-Shoura, LA Abdelzaher, NI Mahmoud… - International …, 2024 - Elsevier
One of the best antipsychotics for treating schizophrenia and bipolar disorders is olanzapine
(OLA). However, its use is restricted owing to unfavorable adverse effects as liver damage …

Protective effects of green tea on olanzapine-induced-metabolic syndrome in rats

BM Razavi, F Lookian, H Hosseinzadeh - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Atypical antipsychotics particularly olanzapine are associated with obesity and serious
metabolic disturbances. As green tea (Camellia sinensis) is generally associated with …

A parametric study of the acute effects of antipsychotic drugs on glucose sensitivity in an animal model

HN Boyda, L Tse, RM Procyshyn, D Wong… - Progress in Neuro …, 2010 - Elsevier
The therapeutic use of atypical antipsychotics is associated with a high incidence of
metabolic side-effects. In the present study we examined the acute effects of both high and …

Routine exercise ameliorates the metabolic side-effects of treatment with the atypical antipsychotic drug olanzapine in rats

HN Boyda, A Ramos-Miguel… - International Journal …, 2014 - academic.oup.com
Second generation antipsychotic (SGA) drugs are effective treatments for psychosis.
Common side-effects of SGAs include metabolic dysregulation and risk of cardiometabolic …

Chronic clozapine treatment in female rats does not induce weight gain or metabolic abnormalities but enhances adiposity: implications for animal models of …

GD Cooper, JA Harrold, JCG Halford… - Progress in Neuro …, 2008 - Elsevier
The ability of clozapine to induce weight gain in female rats was investigated in three studies
with progressively lowered doses of clozapine. In an initial preliminary high dose study …