Conspectus Chain-walking offers extensive opportunities for innovating synthetic methods
that involve constructing chemical bonds at unconventional sites. This approach provides …

For more than 30 years, palladium has been extensively employed in the Suzuki–Miyaura
cross coupling reaction (SMCR) for the synthesis of C–C coupled products. However, Pd …

Key similarities and differences of Pd and Ni in catalytic systems are discussed. Overall, Ni
and Pd catalyze a vast number of similar C–C and C–heteroatom bond-forming reactions …

Design of ligands in transition-metal catalyzed reactions is challenging, especially in
asymmetric transformations. With each step in the catalytic cycle promoted by its privileged …

Regiodivergent alkene functionalization that produces either regioisomer starting from the
same raw materials is desirable. Herein, we report a nickel‐catalyzed switchable site …

A mild and regiodivergent aminoalkylation of unactivated alkyl halides is disclosed via a
dual photoredox/nickel catalysis. Bipyridyl-type ligands without an ortho-substituent control …

A nickel-catalyzed, multicomponent regio-and enantioselective coupling via sequential
hydroformylation and carbonylation from readily available starting materials has been …

A NiH‐catalyzed migratory hydroalkylation of alkenyl amines with predictable and
switchable regioselectivity is reported. By utilizing a ligand‐controlled, directing group …

A NiH-catalyzed thioether-directed cyclometalation strategy is developed to enable remote
methylene C–H bond amidation of unactivated alkenes. Due to the preference for five …

Remote functionalization of alkenes via chain walking has generally been limited to C (sp3)–
H bonds α and β to polar-functional units, while γ-C (sp3)–H functionalization through …