Vitamin B 6 is one of the most central molecules in cells of living organisms. It is a critical co-
factor for a diverse range of biochemical reactions that regulate basic cellular metabolism …

In recent years vitamin B6 has become a focus of research describing the compound's
critical function in cellular metabolism and stress response. For many years the sole function …

Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a
wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin …

Aflatoxins are polyaromatic mycotoxins that contaminate a range of food crops as a result of
fungal growth and contribute to serious health problems in the developing world because of …

Many bacteria and archaea produce the redox cofactor F420. F420 is structurally similar to
the cofactors FAD and FMN but is catalytically more similar to NAD and NADP. These …

The deazaflavin cofactor F 420 enhances the persistence of mycobacteria during hypoxia,
oxidative stress, and antibiotic treatment. However, the identities and functions of the …

Structural genomics projects have revealed structures for a large number of proteins of
unknown function. Understanding the interactions between these proteins and their ligands …

Bilirubin is a potent antioxidant that is produced from the reduction of the heme degradation
product biliverdin. In mammalian cells and Cyanobacteria, NADH/NADPH‐dependent …

The essential biosynthetic pathway to l-Lysine in bacteria and plants is an attractive target
for the development of new antibiotics or herbicides because it is absent in humans, who …

Coenzyme F420 is a deazaflavin hydride carrier with a lower reduction potential than most
flavins. In Mycobacterium tuberculosis (Mtb), F420 plays an important role in activating PA …