Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly
expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved …

Virtual screening (VS) is a powerful technique for identifying hit molecules as starting points
for medicinal chemistry. The number of methods and softwares which use the ligand and …

The pyrazolone structural motif is a critical element of drugs aimed at different biological end-
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …

Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Nuclear receptors (NRs) are ligand-regulated transcription factors that regulate metabolism,
development and immunity. The NR superfamily is one of the major classes of drug targets …

Well‐developed asymmetric organocatalysis has been widely incorporated in various
cascade/tandem sequences, providing a simple access to structurally complex target …

Fatty acids beyond their role as an endogenous energy source and storage are increasingly
considered as signaling molecules regulating various physiological effects in metabolism …

Bile acids are steroid-derived molecules synthesized in the liver, secreted from hepatocytes
into the bile canaliculi, and subsequently stored in the gall bladder. During the feeding, bile …

The modulation of FXR receptor remains an attractive area in drug discovery to develop
novel therapeutic opportunities for liver and metabolic disorders. Despite the large variety of …

Farnesoid X receptor α (FXRα) as a bile acid sensor plays potent roles in multiple metabolic
processes, and its antagonist has recently revealed special interests in the treatment of …