Liver cancer is the third leading cause of cancer death worldwide. Representing such a
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …

Breast cancer cell lines have been widely used for breast cancer modelling which
encompasses a panel of diseases with distinct phenotypical associations. Though cell lines …

The development of cancer is intimately associated with genetic abnormalities that target
proteins with intrinsically disordered regions (IDRs). In human haematological malignancies …

Most current therapies that target plasma membrane receptors function by antagonizing
ligand binding or enzymatic activities. However, typical mammalian proteins comprise …

Serine, glycine and other nonessential amino acids are critical for tumour progression, and
strategies to limit their availability are emerging as potential therapies for cancer,–. However …

Reproducibility in research can be compromised by both biological and technical variation,
but most of the focus is on removing the latter. Here we investigate the effects of biological …

Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency …

We have fully integrated public chromatin chromatin immunoprecipitation sequencing (Ch IP‐
seq) and DN ase‐seq data (n> 70,000) derived from six representative model organisms …

DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at
cytosines is essential for genome regulation and development,. Dysregulation of this …

Compared with normal cells, tumor cells have undergone an array of genetic and epigenetic
alterations. Often, these changes underlie cancer development, progression, and drug …