Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

DV Bhalani, B Nutan, A Kumar, AK Singh Chandel - Biomedicines, 2022 - mdpi.com
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Plants in anticancer drug discovery: from molecular mechanism to chemoprevention

AJ Siddiqui, S Jahan, R Singh, J Saxena… - BioMed Research …, 2022 - Wiley Online Library
Cancer is one of the primary causes of mortality globally, and the discovery of new
anticancer drugs is the most important need in recent times. Natural products have been …

[HTML][HTML] Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

M Elmowafy, MM Al-Sanea - Saudi Pharmaceutical Journal, 2021 - Elsevier
NLCs have provoked the incessant impulsion for the development of safe and valuable drug
delivery systems owing to their exceptional physicochemical and then biocompatible …

[HTML][HTML] Solid lipid nanoparticle-based dissolving microneedles: A promising intradermal lymph targeting drug delivery system with potential for enhanced treatment of …

AD Permana, IA Tekko, MTC McCrudden… - Journal of controlled …, 2019 - Elsevier
Conventional oral therapy of lymphatic filariasis drugs is only effective to kill microfilariae in
the bloodstream, but is often ineffective to kill adult filarial (macrofilariae) in the complex …

Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H Xing, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

[HTML][HTML] Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

YK Mahmoud, HMA Abdelrazek - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Recently, there is growing interest in the natural bioactive components having anticancer
activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa) …

Encapsulation of phenolic compounds within nano/microemulsion systems: A review

F Garavand, M Jalai-Jivan, E Assadpour, SM Jafari - Food Chemistry, 2021 - Elsevier
Phenolic compounds (phenolics) have received great attention in the food, pharmaceutical
and nutraceutical industries due to their health-promoting attributes. However, their …

[HTML][HTML] Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

A Ahmad, RK Mishra, A Vyawahare, A Kumar… - Saudi Pharmaceutical …, 2019 - Elsevier
Cancer remains the topmost disorder of the mankind and number of cases is unceasingly
growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the …

Topoisomerase II poisons: converting essential enzymes into molecular scissors

KR Vann, AA Oviatt, N Osheroff - Biochemistry, 2021 - ACS Publications
The extensive length, compaction, and interwound nature of DNA, together with its
controlled and restricted movement in eukaryotic cells, create a number of topological issues …

Thymoquinone: A promising natural compound with potential benefits for COVID-19 prevention and cure

OA Badary, MS Hamza, R Tikamdas - Drug design, development …, 2021 - Taylor & Francis
COVID-19 has caused a major global health crisis, as excessive inflammation, oxidation,
and exaggerated immune response in some sufferers can lead to a condition known as …