Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …

The Bacillus cereus group includes several Bacillus species with closely related phylogeny.
The most well-studied members of the group, B. anthracis, B. cereus, and B. thuringiensis …

Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic
Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ …

Neuroinflammation is one of the most striking hallmarks of amyotrophic lateral sclerosis
(ALS). Nuclear factor-kappa B (NF-κB), a master regulator of inflammation, is upregulated in …

Conventional type 1 dendritic cells (cDC1s) are critical for antitumor immunity. They acquire
antigens from dying tumor cells and cross-present them to CD8+ T cells, promoting the …

Bacterial sepsis is a major cause of fatality worldwide. Sepsis is a multi-step process that
involves an uncontrolled inflammatory response by the host cells that may result in multi …

A link between inflammation and cancer has long been suspected, but its molecular nature
remained ill defined. A key player in inflammation is transcription factor NF-κB whose activity …

Cells are continuously exposed to a variety of environmental stresses and have to decide 'to
be or not to be'depending on the types and strength of stress. Among the many signaling …

Bioterrorism has received a lot of attention in the first decade of this century. Biological
agents are considered attractive weapons for bioterrorism as these are easy to obtain …

Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety
of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate …