Stroke is a serious neurological disease, and constitutes a major cause of death and
disability throughout the world. The pathophysiology of stroke is complex, and involves …

Contrary to previous dogmas, it is now well established that brain cells can produce
cytokines and chemokines, and can express adhesion molecules that enable an in situ …

The results of several experimental studies of focal ischemia and anecdotal observations
suggest that leukocytes may contribute to the injury initiated by an arterial occlusion. The …

Cyclo-oxygenase-2 (COX-2), a rate-limiting enzyme for prostanoid synthesis, is induced
during inflammation and participates in inflammation-mediated cytotoxicity. Cerebral …

Background—In this review we discuss the role of inflammatory cell adhesion molecules
(CAMs) in ischemic stroke and in delayed cerebral ischemia after subarachnoid …

Acute neutrophil (PMN) recruitment to postischemic cardiac or pulmonary tissue has
deleterious effects in the early reperfusion period, but the mechanisms and effects of …

The extent to which polymorphonuclear leukocytes and monocytes/macrophages contribute
to the pathobiology of cerebral ischemia and stroke is an issue of long-standing …

Cerebral ischemia is followed by a local inflammatory response that is thought to participate
in the extension of the tissue damage occurring in the postischemic period. However, the …

Abstract RECENT EVIDENCE INDICATES that thrombolysis may be an effective therapy for
the treatment of acute ischemic stroke. However, the reperfusion of ischemic brain comes …

Reperfusion injury following ischemic stroke is a complex pathophysiological process
involving numerous mechanisms ranging from the release of excitatory amino acids and ion …