GnRH and its analogs are used extensively for the treatment of hormone-dependent
diseases and assisted reproductive techniques. They also have potential as novel …

The superfamily of G-protein-coupled receptors (GPCRs) could be subclassified into 7
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors constitute
the largest family of eukaryotic signal transduction proteins that communicate across the …

G protein-coupled receptors (GPCRs) respond to a diverse array of ligands, mediating
cellular responses to hormones and neurotransmitters, as well as the senses of smell and …

The classical idea that G‐protein‐coupled receptors (GPCRs) function as monomeric
entities has been unsettled by the emerging concept of GPCR dimerization. Recent findings …

G protein–coupled receptors (GPCRs) mediate transmembrane signaling. Before ligand
binding, GPCRs exist in a basal state. Crystal structures of several GPCRs bound with …

There is evidence for strong functional antagonistic interactions between adenosine A 2A
receptors (A 2A Rs) and dopamine D 2 receptors (D 2 Rs). Although a close physical …

G protein–coupled receptor (GPCR) oligomers have been proposed to play critical roles in
cell signaling, but confirmation of their existence in a native context remains elusive, as no …

G protein-coupled receptors (GPCRs), which constitute the largest and structurally best
conserved family of signaling molecules, are involved in virtually all physiological …

▪ Abstract The multitude of chemically highly different agonists for 7TM receptors apparently
do not share a common binding mode or active site but nevertheless act through induction of …