There are currently more than 600 diseases characterized as affecting the central nervous
system (CNS) which inflict neural damage. Unfortunately, few of these conditions have …

Synaptic neurotransmission relies on maintenance of the synapse and meeting the energy
demands of neurons. Defects in excitatory and inhibitory synapses have been implicated in …

Major depressive disorder (MDD) is a prevalent and serious mental disorder with high rates
of suicide and disability. However, the underlying pathogenesis of MDD is complicated and …

Brain is still an organ with a composition to be discovered but beyond that, mental disorders
and especially all diseases that curse with dementia are devastating for the patient, the …

On observing schizophrenia from a clinical point of view up to its molecular basis, one may
conclude that this is likely to be one of the most complex human disorders to be …

Major depressive disorder (MDD) is a highly prevalent, debilitating mental illness of
importance for global health. However, its molecular pathophysiology remains poorly …

These results support that ketogenic diet may present a novel therapeutic approach through
restoring brain energy metabolism in schizophrenia. Randomized controlled clinical trials …

GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and
dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable …

The purpose of this article is to provide a comprehensive review of metabolomics studies for
psychosis, as a means of biomarker discovery. Manuscripts were selected for review if they …

Approximately 25% of the world population is affected by a mental disorder at some point in
their life. Yet, only in the mid-twentieth century a biological cause has been proposed for …