Cannabinoids: therapeutic use in clinical practice
Medical case reports suggest that cannabinoids extracted from Cannabis sativa have
therapeutic effects; however, the therapeutic employment is limited due to the psychotropic …
therapeutic effects; however, the therapeutic employment is limited due to the psychotropic …
Getting the “kill” into “shock and kill”: strategies to eliminate latent HIV
Y Kim, JL Anderson, SR Lewin - Cell host & microbe, 2018 - cell.com
Despite the success of antiretroviral therapy (ART), there is currently no HIV cure and
treatment is life long. HIV persists during ART due to long-lived and proliferating latently …
treatment is life long. HIV persists during ART due to long-lived and proliferating latently …
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
NF McMyn, J Varriale, EJ Fray… - The Journal of …, 2023 - Am Soc Clin Investig
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …
Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses
HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently
considered" transcriptionally silent," but active viral gene expression may occur in some …
considered" transcriptionally silent," but active viral gene expression may occur in some …
Prolonged viral suppression with anti-HIV-1 antibody therapy
HIV-1 infection remains a public health problem with no cure. Anti-retroviral therapy (ART) is
effective but requires lifelong drug administration owing to a stable reservoir of latent …
effective but requires lifelong drug administration owing to a stable reservoir of latent …
[HTML][HTML] HIV-1 remission and possible cure in a woman after haplo-cord blood transplant
Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32)
allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in …
allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in …
Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
Defining total-body AIDS-virus burden with implications for curative strategies
JD Estes, C Kityo, F Ssali, L Swainson… - Nature medicine, 2017 - nature.com
In the quest for a functional cure or the eradication of HIV infection, it is necessary to know
the sizes of the reservoirs from which infection rebounds after treatment interruption. Thus …
the sizes of the reservoirs from which infection rebounds after treatment interruption. Thus …
Persistent HIV-1 replication maintains the tissue reservoir during therapy
Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site
associated with viral production, storage of viral particles in immune complexes, and viral …
associated with viral production, storage of viral particles in immune complexes, and viral …