Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We developed a …

Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Apoptosis plays a major role in shaping the developing nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …

Chemotherapeutic agents cause many short and long term toxic side effects to peripheral
nervous system (PNS) that drastically alter quality of life. Chemotherapy-induced peripheral …

Chemotherapy-induced peripheral neuropathy is one of the most prevalent dose-limiting
toxicities of anticancer therapy. Development of effective therapies to prevent chemotherapy …

Nervous system function depends on proper myelination for insulation and critical trophic
support for axons. Myelination is tightly regulated spatially and temporally, but how it is …

Axonal degeneration and neuronal cell death are fundamental processes in development
and contribute to the pathology of neurological disease in adults. Both processes are …

Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to
axonal damage in retinal ganglion cells (RGCs) and other neurons. To better understand the …