The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules
between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC) …

INTRODUCTION The nuclear pore complex (NPC) is the primary gateway for the transport of
macromolecules between the nucleus and cytoplasm, serving as both a critical mediator and …

In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and
translation in the cytoplasm imposes the requirement of transporting thousands of …

The association of genes with the nuclear pore complex (NPC) and nuclear transport factors
has been implicated in transcriptional regulation. We therefore examined the association of …

Nuclear pore complexes (NPCs) are large proteinaceous assemblies that provide the only
known portals for exchanging macromolecules between the nucleus and cytoplasm. This …

The nuclear envelope is a physical barrier between the nucleus and cytoplasm and, as
such, separates the mechanisms of transcription from translation. This compartmentalization …

Toward dissecting the molecular composition and architecture of the nuclear pore complex
(NPC), over the past 18 months novel nucleoporins and NPC subcomplexes were identified …

The nuclear pore complexes (NPCs) are evolutionarily conserved assemblies that allow
traffic between the cytoplasm and the nucleus. In this study, we have identified and …