Brain inflammation is a major factor in epilepsy, but the impact of specific inflammatory
mediators on neuronal excitability is incompletely understood. Using models of acute and …

Relevant to the definition of epileptic encephalopathy (EE) is the concept that the epileptic
activity itself may contribute to bad outcomes, both in terms of epilepsy and cognition, above …

Experimental evidence and clinical observations indicate that brain inflammation is an
important factor in epilepsy. In particular, induction of interleukin-converting enzyme …

Epileptogenesis is the process of developing an epileptic condition and/or its progression
once it is established. The molecules that initiate, promote, and propagate remarkable …

Abstract Toll-like receptor 4 (TLR4) activation in neuron and astrocytes by High Mobility
Group Box 1 (HMGB1) protein is a key mechanism of seizure generation. HMGB1 also …

Although minocycline has been generally thought to have neuroprotective properties, the
neuroprotective role of minocycline has not been investigated in the animal model of …

In humans, temporal lobe epilepsy (TLE) is often associated with Ammon's horn sclerosis
(AHS) characterized by hippocampal cell death, gliosis and granule cell dispersion (GCD) in …

The AMPA receptor subtype of glutamate receptors, which mediates fast synaptic excitation,
is of primary importance in initiating epileptiform discharges, so that AMPA receptor …

Recent studies in animal models have suggested that the mammalian target of rapamycin
(mTOR) signaling pathway is involved in several features of mesio‐temporal lobe epilepsy …

Purpose Sudden unexplained death in childhood (SUDC), while rare, accounts for an
important fraction of unexpected deaths in children> 1 year of age. Previously we reported …