Modulation of neural co-firing to enhance network transmission and improve motor function after stroke
Stroke is a leading cause of disability. While neurotechnology has shown promise for
improving upper limb recovery after stroke, efficacy in clinical trials has been variable. Our …
improving upper limb recovery after stroke, efficacy in clinical trials has been variable. Our …
The basal ganglia control the detailed kinematics of learned motor skills
The basal ganglia are known to influence action selection and modulation of movement
vigor, but whether and how they contribute to specifying the kinematics of learned motor …
vigor, but whether and how they contribute to specifying the kinematics of learned motor …
[HTML][HTML] Integrating across behaviors and timescales to understand the neural control of movement
The nervous system evolved to enable navigation throughout the environment in the pursuit
of resources. Evolutionarily newer structures allowed increasingly complex adaptations but …
of resources. Evolutionarily newer structures allowed increasingly complex adaptations but …
Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice
The basal ganglia are essential for executing motor actions. How the basal ganglia engage
spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons …
spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons …
Action suppression reveals opponent parallel control via striatal circuits
The direct and indirect pathways of the basal ganglia are classically thought to promote and
suppress action, respectively. However, the observed co-activation of striatal direct and …
suppress action, respectively. However, the observed co-activation of striatal direct and …
Dissociating the contributions of sensorimotor striatum to automatic and visually guided motor sequences
The ability to sequence movements in response to new task demands enables rich and
adaptive behavior. However, such flexibility is computationally costly and can result in …
adaptive behavior. However, such flexibility is computationally costly and can result in …
Striatal direct pathway targets Npas1+ pallidal neurons
The classic basal ganglia circuit model asserts a complete segregation of the two striatal
output pathways. Empirical data argue that, in addition to indirect-pathway striatal projection …
output pathways. Empirical data argue that, in addition to indirect-pathway striatal projection …
Dissociable roles of pallidal neuron subtypes in regulating motor patterns
We have previously established that PV+ neurons and Npas1+ neurons are distinct neuron
classes in the external globus pallidus (GPe): they have different topographical …
classes in the external globus pallidus (GPe): they have different topographical …
Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia
E Wärnberg, A Kumar - Proceedings of the National …, 2023 - National Acad Sciences
It is well established that midbrain dopaminergic neurons support reinforcement learning
(RL) in the basal ganglia by transmitting a reward prediction error (RPE) to the striatum. In …
(RL) in the basal ganglia by transmitting a reward prediction error (RPE) to the striatum. In …
Hindbrain modules differentially transform activity of single collicular neurons to coordinate movements
Seemingly simple behaviors such as swatting a mosquito or glancing at a signpost involve
the precise coordination of multiple body parts. Neural control of coordinated movements is …
the precise coordination of multiple body parts. Neural control of coordinated movements is …