Cancer genome-sequencing studies have revealed a remarkably high prevalence of
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …

Genes encoding SWI/SNF chromatin remodeling complex subunits are collectively mutated
in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein …

DNA sequencing-based studies of neurodevelopmental disorders (NDDs) have identified a
wide range of genetic determinants. However, a comprehensive analysis of these data, in …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …

Deep catalogs of genetic variation from thousands of humans enable the detection of
intraspecies constraint by identifying coding regions with a scarcity of variation. While …

Recent genome-sequencing studies in human neurodevelopmental and psychiatric
disorders have uncovered mutations in many chromatin regulators. These human genetic …

The ATP-dependent BRG1/BRM associated factor (BAF) chromatin remodeling complexes
are crucial in regulating gene expression by controlling chromatin dynamics. Over the last …

Adenoid cystic carcinomas (ACCs) are among the most enigmatic of human malignancies.
These aggressive salivary gland cancers frequently recur and metastasize despite definitive …

Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers
are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding …