Current state and future directions in the therapy of ALS

L Tzeplaeff, S Wilfling, MV Requardt, M Herdick - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …

Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases

JA Santiago, JA Potashkin - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases have reached alarming numbers in the past decade.
Unfortunately, clinical trials testing potential therapeutics have proven futile. In the absence …

Brain vascular health in ALS is mediated through motor cortex microvascular integrity

S Schreiber, J Bernal, P Arndt, F Schreiber, P Müller… - Cells, 2023 - mdpi.com
Brain vascular health appears to be critical for preventing the development of amyotrophic
lateral sclerosis (ALS) and slowing its progression. ALS patients often demonstrate …

[图书][B] Advanced neuromuscular exercise physiology

P Gardiner - 2024 - books.google.com
Advanced Neuromuscular Exercise Physiology, Second Edition, uses a mix of biochemistry,
molecular biology, neurophysiology, and muscle physiology to provide a synthesis of …

Wheel running adversely affects disease onset and neuromuscular interplay in amyotrophic lateral sclerosis slow progression mouse model

E Golini, S Marinelli, S Pisu… - Current …, 2023 - ingentaconnect.com
Background: Physical activity in Amyotrophic Lateral Sclerosis (ALS) plays a controversial
role. In some epidemiological studies, both recreational or professional sport exercise has …

Telehealth-based exercise in amyotrophic lateral sclerosis

V Kudritzki, IM Howard - Frontiers in Neurology, 2023 - frontiersin.org
The Veterans Health Administration (VHA) has served as a leader in the implementation of
telerehabilitation technologies and continues to expand utilization of non-traditional patient …

Efficacy of non-pharmacological interventions for individuals with amyotrophic lateral sclerosis: systematic review and network meta-analysis of randomized control …

Z Li, H Kang - Scientific Reports, 2024 - nature.com
This network meta-analysis (NMA) aimed to compare the efficacy of five non-
pharmacological interventions, including exercise intervention (EI), nutritional intervention …

Genetic causal role of body mass index in multiple neurological diseases

X Wang, H Chen, Z Chang, J Zhang, D Xie - Scientific Reports, 2024 - nature.com
Body mass index (BMI) is a crucial health indicator for obesity. With the progression of socio-
economic status and alterations in lifestyle, an increasing number of global populations are …

Chronological and Biological Aging in Amyotrophic Lateral Sclerosis and the Potential of Senolytic Therapies

AR Dashtmian, FB Darvishi, WD Arnold - Cells, 2024 - mdpi.com
Amyotrophic Lateral Sclerosis (ALS) is a group of sporadic and genetic neurodegenerative
disorders that result in losses of upper and lower motor neurons. Treatment of ALS is limited …

Enhancing ALS disease management: exploring integrated user value through online communities evidence

J Hruška, P Bachmann, SA Odei - Frontiers in Neurology, 2025 - frontiersin.org
Introduction Assistive technologies (ATs) offer significant potential to improve the quality of
life for individuals with Amyotrophic Lateral Sclerosis (ALS). This study explores the concept …