Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in
energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now …

Palatable food can be seductive and hedonic eating can become irresistible beyond hunger
and negative consequences. This is witnessed by the subtle equilibrium between eating to …

Overeating, frequently linked to an increasing incidence of overweight and obesity, has
become epidemic and one of the leading global health problems. To explain the …

Gut-brain signaling controls food intake and energy homeostasis, and its activity is thought
to be dysregulated in obesity. We will explore new studies that suggest the …

Abstract Purpose of the Review The endocannabinoid system (ENS) has emerged as an
important factor in food intake and may have implications for nutrition research. The …

Overeating typically follows periods of energy deficit, but it is also sustained by highly
palatable foods, even without metabolic demand. Dopamine D1 receptor-expressing …

The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized,
while the precise molecular and cellular mechanisms involved are the focus of intense …

Background and Purpose The development of potent and selective inhibitors of the
biosynthesis of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) via DAG lipases …

A review of the scientific evidence on the effects of cannabinoids on brain and behavioral
functioning, with an emphasis on potential therapeutic use. The cannabis plant has been …

The endocannabinoid system plays an important role in the intake of palatable food. For
example, endocannabinoid signaling in the upper small-intestinal epithelium is increased (i) …