[HTML][HTML] Behavioral effects of space radiation: A comprehensive review of animal studies

F Kiffer, M Boerma, A Allen - Life sciences in space research, 2019 - Elsevier
As NASA prepares for the first manned mission to Mars in the next 20 years, close attention
has been placed on the cognitive welfare of astronauts, who will likely endure extended …

Central nervous system responses to simulated galactic cosmic rays

E Cekanaviciute, S Rosi, SV Costes - International journal of molecular …, 2018 - mdpi.com
In preparation for lunar and Mars missions it is essential to consider the challenges to
human health that are posed by long-duration deep space habitation via multiple stressors …

Female mice are protected from space radiation-induced maladaptive responses

K Krukowski, K Grue, ES Frias, J Pietrykowski… - Brain, behavior, and …, 2018 - Elsevier
Interplanetary exploration will be humankind's most ambitious expedition and the journey
required to do so, is as intimidating as it is intrepid. One major obstacle for successful deep …

Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits

K Krukowski, X Feng, MS Paladini, A Chou… - Scientific reports, 2018 - nature.com
Microglia are the main immune component in the brain that can regulate neuronal health
and synapse function. Exposure to cosmic radiation can cause long-term cognitive …

Combined effects of three high-energy charged particle beams important for space flight on brain, behavioral and cognitive endpoints in B6D2F1 female and male …

J Raber, J Yamazaki, ERS Torres, N Kirchoff… - Frontiers in …, 2019 - frontiersin.org
The radiation environment in deep space includes the galactic cosmic radiation with
different proportions of all naturally occurring ions from protons to uranium. Most …

Risks of cognitive detriments after low dose heavy ion and proton exposures

FA Cucinotta, E Cacao - International journal of radiation biology, 2019 - Taylor & Francis
Purpose: Heavy ion and proton brain irradiations occur during space travel and in Hadron
therapy for cancer. Heavy ions produce distinct patterns of energy deposition in neuron cells …

Galactic cosmic radiation induces persistent epigenome alterations relevant to human lung cancer

EM Kennedy, DR Powell, Z Li, JSK Bell, BG Barwick… - Scientific reports, 2018 - nature.com
Human deep space and planetary travel is limited by uncertainties regarding the health risks
associated with exposure to galactic cosmic radiation (GCR), and in particular the high …

Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma …

J Raber, M Chaudhari, A De la Torre, S Holden… - Frontiers in …, 2024 - frontiersin.org
Introduction Effects and interactions between different spaceflight stressors are expected to
be experienced by crew on missions when exposed to microgravity and galactic cosmic rays …

Amifostine (WR-2721) Mitigates cognitive injury induced by heavy ion radiation in male mice and alters behavior and brain connectivity

SW Boutros, B Zimmerman, SC Nagy, JS Lee… - Frontiers in …, 2021 - frontiersin.org
The deep space environment contains many risks to astronauts during space missions, such
as galactic cosmic rays (GCRs) comprised of naturally occurring heavy ions. Heavy ion …

The effects of galactic cosmic rays on the central nervous system: From negative to unexpectedly positive effects that astronauts may encounter

VS Kokhan, MI Dobynde - Biology, 2023 - mdpi.com
Simple Summary The central nervous system is extremely sensitive to cosmic rays–an
ionizing radiation that astronauts encounter during interplanetary missions, particularly to …