[HTML][HTML] The Dynorphin/-Opioid Receptor System at the Interface of Hyperalgesia/Hyperkatifeia and Addiction

RCN Marchette, LF Vendruscolo, GF Koob - Current Addiction Reports, 2025 - Springer
Abstract Purpose of Review Drug addiction is characterized by compulsive drug seeking
and use, accompanied by negative emotional states (hyperkatifeia) and heightened pain …

Opioid ligands may act by blocking the muscarinic anti-inflammatory effect through allostericity in M1 receptors

SG Sousa, D de Aguiar Magalhães, JA Batista… - Medical …, 2023 - Elsevier
Muscarinic receptors are also involved in the cholinergic anti-inflammatory function through
a central mechanism, as well as a peripheral one, which was recently evidenced. The …

Detection of dynorphin 1-17 biotransformation fragments in human nasal polyps by UPLC-QTOF-MS

R Ballouze, MN Ismail, NS Abu Kassim… - Analytical and …, 2024 - Springer
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammation of the
sinonasal mucosa. CRSwNP treatments are associated with inconsistent efficacy and …