ADME and toxicity considerations for tramadol: from basic research to clinical implications

M Doostmohammadi, HR Rahimi - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction Tramadol is widely being used in chronic pain management for improving
patients' life quality and reducing trauma. Although it is listed in several medicinal …

[PDF][PDF] Tramadol-induced organ toxicity via oxidative stress: a review study

L Mohammadnejad, K Soltaninejad - International Journal of …, 2022 - academia.edu
Background: Tramadol (TR) is a synthetic opioid-like centrally acting analgesic used for
moderate to severe pain management in various diseases. Numerous investigations have …

Evaluation of mitochondrial dysfunction due to oxidative stress in therapeutic, toxic and lethal concentrations of tramadol

L Mohammadnejad, K Soltaninejad… - Toxicology …, 2021 - academic.oup.com
Tramadol (TR) is a centrally acting analgesic drug that is used to relieve pain. The
therapeutic (0.1–0.8 mg/l), toxic (1–2 mg/l) and lethal (> 2 mg/l) ranges were reported for TR …

Maternotoxicity and fetotoxicity in Rattus norvegicus albinus exposed to tramadol during the late phase of pregnancy

MF Akhtar, S Younas, A Saleem… - Birth Defects …, 2021 - Wiley Online Library
Objectives Tramadol, an atypical opioid, is clinically efficacious in treating moderate to
severe pain. The aim of current study was to find out the toxicological effects of tramadol …

Morphometric, hematological and oxidative stress changes in Clarias gariepinus following sub-chronic exposure to tramadol

FI Ogili, D Ali, GN Attamah, U Aletan, HI Kelle… - … and Physiology Part C …, 2021 - Elsevier
Tramadol is among the most famous analgesic drugs used for the management, treatment
and relief of moderate to severe pain conditions. The present study investigated the effects …

[PDF][PDF] Studies of Salvia officinalis leaf extract on some biochemical parameters in rats induced with overdosed-tramadol

ATH Mokogwu, CO Adjekuko, HU Oshilonyah… - Afr J …, 2022 - academicjournals.org
The aim of the study was to evaluate the effect of Salvia officinalis leaf extract in overdosed-
tramadol induced rats. Standard methods of analysis were used for the study. Fifty rats were …

Hematological, biochemical, and biometric changes in Clarias gariepinus exposed to antipsychotic drug chlorpromazine

MN Okpe, CC Eze, HC Ezinwa, U Aletan… - … Science and Pollution …, 2023 - Springer
Chlorpromazine (CPZ) is a neuroleptic and antipsychotic medication for individuals suffering
from schizophrenia and other medical conditions. This study investigated the effects of CPZ …

[HTML][HTML] Tramadol abuse and addiction: effects on learning, memory, and organ damage

LU Zebedee, MW Bariweni, YI Oboma… - Egyptian …, 2022 - journals.lww.com
Background Addiction to controlled or prescription drugs is an increasing health burden in
most countries and Nigeria is not an exception. Tramadol abuse is a menace in Nigeria …

Protective effects of barley and wheat grasses on nephrotoxicity in rats and some biochemical parameters induced by tramadol

HSE Eldamaty - Egyptian Journal of Nutrition and Health, 2020 - journals.ekb.eg
The present study was conducted to evaluate the protective effects of barley and wheat
grasses against tramadol induced nephrotoxicity, biochemical changes as well as oxidative …

Modulatory activities of polyphenols on crude acetylene-induced cardiac and hepatic dysfunctions in a rat model

OO Aladesanmi, AC Akinmoladun… - Drug and Chemical …, 2022 - Taylor & Francis
Exposure to crude acetylene can occur in occupational settings. This study assessed the
modulatory activities of selected polyphenols on the hematotoxic, cardiotoxic, and …