Eosinophils are evolutionarily conserved, pleotropic cells that display key effector functions
in allergic diseases, such as asthma. Nonetheless, eosinophils infiltrate multiple tumours …

Tumor hypoxia resulting from abnormal and dysfunctional tumor vascular network poses a
substantial obstacle to immunotherapy. In fact, hypoxia creates an immunosuppressive …

Prolonged low-grade inflammation or smoldering inflammation is a hallmark of a cancer.
Eosinophils are components of the immune microenvironment that modulates tumor …

Eosinophils derive from the bone marrow and circulate at low levels in the blood in healthy
individuals. These granulated cells preferentially leave the circulation and marginate to …

The use of various transgenic mouse models and analysis of human tumour biopsies has
shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils …

Eosinophils have long been known to infiltrate tumors, and in most cases, this is associated
with an improved prognosis. However, the reasons behind this infiltration and the …

Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4
(CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition …

The role of IL‐33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer
model we demonstrate time‐dependent increase of endogenous IL‐33 at both the mRNA …

IL-5 is involved in a number of immune responses such as helminth infection and allergy. IL-
5 also plays roles in innate immunity by maintaining B-1 B cells and mucosal IgA production …

Originally characterized as angiogenic factors, fibroblast growth factors (FGFs) are
pleiotropic factors that exert autocrine and paracrine functions on tumor and stromal cells …