Detecting awareness after severe brain injury

D Fernández-Espejo, AM Owen - Nature Reviews Neuroscience, 2013 - nature.com
Recent developments in functional neuroimaging have provided a number of new tools for
assessing patients who clinically appear to be in a vegetative state. These techniques have …

Towards clinical application of implantable brain–computer interfaces for people with late-stage ALS: medical and ethical considerations

MJ Vansteensel, E Klein, G van Thiel, M Gaytant… - Journal of …, 2023 - Springer
Individuals with amyotrophic lateral sclerosis (ALS) frequently develop speech and
communication problems in the course of their disease. Currently available augmentative …

Cognitive motor dissociation: gap analysis and future directions

J Claassen, D Kondziella, A Alkhachroum, M Diringer… - Neurocritical care, 2024 - Springer
Background Patients with disorders of consciousness who are behaviorally unresponsive
may demonstrate volitional brain responses to motor imagery or motor commands …

Making every word count for nonresponsive patients

L Naci, AM Owen - JAMA neurology, 2013 - jamanetwork.com
Importance Despite the apparent absence of external signs of consciousness, a significant
small proportion of patients with disorders of consciousness can respond to commands by …

A thalamocortical mechanism for the absence of overt motor behavior in covertly aware patients

D Fernández-Espejo, S Rossit, AM Owen - JAMA neurology, 2015 - jamanetwork.com
Importance It is well accepted that a significant number of patients in a vegetative state are
covertly aware and capable of following commands by modulating their neural responses in …

Flowchart for implementing advanced imaging and electrophysiology in patients with disorders of consciousness: to fMRI or not to fMRI?

MM Monti, C Schnakers - Neurology, 2022 - AAN Enterprises
The American Academy of Neurology and the European Academy of Neurology have
recognized, for the first time, the value of advanced neuroimaging and electrophysiology …

Indicators and criteria of consciousness in animals and intelligent machines: an inside-out approach

CMA Pennartz, M Farisco, K Evers - Frontiers in systems neuroscience, 2019 - frontiersin.org
In today's society, it becomes increasingly important to assess which non-human and non-
verbal beings possess consciousness. This review article aims to delineate criteria for …

What justifies the allocation of health care resources to patients with disorders of consciousness?

A Peterson, S Aas, D Wasserman - AJOB neuroscience, 2021 - Taylor & Francis
This paper critically engages ethical issues in the allocation of novel, and potentially costly,
health care resources to patients with disorders of consciousness. First, we review potential …

Electrophysiological evidence of preserved hearing at the end of life

EG Blundon, RE Gallagher, LM Ward - Scientific reports, 2020 - nature.com
This study attempts to answer the question:“Is hearing the last to go?” We present evidence
of hearing among unresponsive actively dying hospice patients. Individual ERP (MMN, P3a …

Ethics along the continuum of research involving persons with disorders of consciousness

A Lewis, MJ Young, B Rohaut, RJ Jox, J Claassen… - Neurocritical care, 2023 - Springer
Interest in disorders of consciousness (DoC) has grown substantially over the past decade
and has illuminated the importance of improving understanding of DoC biology; care needs …