Abstract Type 2 diabetes (T2D) is a polygenic and multifactorial complex disease, defined as
chronic metabolic disorder. It's a major global health concern with an estimated 463 million …

Inbred mouse strains play a critical role in biomedical research. Genetic homogeneity within
inbred strains and their general amenability to genetic manipulation have made them an …

Thermogenic brown adipose tissue (BAT) has emerged as an attractive target for combating
obesity. However, pharmacological activation of energy expenditure by BAT and/or …

Rationale The extent of heart disease varies from person to person, suggesting that genetic
background is important in pathology. Genetic background is also important when selecting …

В монографии проведен анализ современных представлений о роли и оценке
физиологических констант в физиологических и пато-физиологических экспериментах …

Elevated heart rate (HR) is a risk factor for cardiovascular diseases. The goal of the study
was to map HR trait in mice using quantitative trait locus (QTL) analysis followed by genome …

In this chapter, we will use the example of the identification of Tnni3k as a modulator of
cardiac conduction to introduce you to the use of a murine F2-generation intercross as a …

Understanding the genetic influence on vascular reactivity is important for identifying genes
underlying impaired vascular function. The purpose of this study was to characterize the …

There are advantages and limitations to using genetically heterogeneous stocks and
selective breeding procedures in gerontological and healthspan research. Animal models …

The predominance of age-related diseases such as Alzheimer's disease (AD) are projected
to double over the next several decades, which is attributed to the rapidly growing aging …