Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and has a unique
metastatic route using ascites, known as the transcoelomic root. However, studies on ascites …

The ovarian cancer tumor microenvironment (TME) consists of a constellation of abundant
cellular components, extracellular matrix, and soluble factors. Soluble factors, such as …

Cancer-associated fibroblasts (CAFs), an important type of stromal cells in the tumor
microenvironment (TME), are responsible for creating physical barriers to drug delivery and …

The traditional evaluation of nanoparticles (NPs) is mainly based on 2D cell culture and
animal models. However, these models are difficult to accurately represent human tumor …

Melanoma is the most aggressive and fatal type of skin cancer due to being highly
proliferative. Acetylsalicylic acid (ASA; Aspirin) and salicylic acid (SA) are ancient drugs with …

In the attempts to mitigate uncertainties in the results of monolayer culture for the
identification of cancer therapeutic targets and compounds, there has been a growing …

The multistep metastasis process is carried out by the combinatorial effect of the stromal
cells and the cancerous cells and plays vital role in the cancer progression. The …

Infantile hemangioma (IH) is the most prevalent benign vascular tumor in infants, with
distinct disease stages and durations. Despite the fact that the majority of IHs can regress …

Three-dimensional cell culture technology (3DCC) sits between two-dimensional cell culture
(2DCC) and animal models and is widely used in oncology research. Compared to 2DCC …

Heterogeneity is a characteristic feature of solid tumors. Intra-tumor heterogeneity includes
phenotypic diversity, epigenetic abnormalities, cell proliferation, and plasticity that eventually …