Introduction Due to the segmented functions and complexity of the human brain, the
characterization of molecular profiles within specific areas such as brain structures and …

Intratumoral heterogeneity can wreak havoc on current precision medicine strategies
because of challenges in sufficient sampling of geographically separated areas of …

Genome-wide association studies (GWASs) have identified risk loci for suicide attempt (SA),
but deciphering how they confer risk for SA remains largely unknown. This study aims to …

Many malignant cancers like glioblastoma are highly adaptive diseases that dynamically
change their regional biology to survive and thrive under diverse microenvironmental and …

Glioblastoma is often subdivided into three transcriptional subtypes (classical, proneural,
mesenchymal) based on bulk RNA signatures that correlate with distinct genetic and clinical …

Intra-tumoral heterogeneity can wreak havoc on current precision medicine strategies due to
challenges in sufficient sampling of geographically separated areas of biodiversity …

In an era of unparalleled technical advancement, the pharmaceutical industry is struggling to
transform data into increased research and development efficiency, and, as a corollary, new …

Abstract Chitinase-3-like protein 1 (CHI3L1) is a secreted, non-enzymatic glycoprotein that
binds proteins and carbohydrates and interacts with cell-surface and extracellular-matrix …

Glycosylation is a keystone of mammalian cells found primarily on membrane proteins and
lipids, extending into the extracellular space to form the outer-most membrane layer known …